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Link compounds to protein targets, rank bioactivity, and look up drug mechanisms and indications.
io.github.cyanheads/chembl-mcp-server is an MCP server entry in ChatHome Skills, sourced from Official MCP Registry and scored 78/100. As a Model Context Protocol server, it exposes tools that MCP-compatible LLM clients such as Claude, Cursor, and Copilot can call directly, extending an agent's reach beyond its built-in capabilities. ChatHome Skills discovered this entry through its daily ingest of official registries and GitHub discovery queries, and re-verifies repository facts, freshness signals, and install metadata on every run. The quality score weighs official-registry presence, a working install command, license clarity, GitHub star trajectory, and repository freshness — the full formula is on the Sources page. The install command above is ready to copy. Review the last-pushed date and repository status before adding io.github.cyanheads/chembl-mcp-server to a production agent workflow; the snapshot facts below are point-in-time values from the most recent ingest.
mcp add io.github.cyanheads/chembl-mcp-server https://chembl.caseyjhand.com/mcpReview the upstream source before running this command.
{
"_meta": {
"io.modelcontextprotocol.registry/official": {
"status": "active",
"isLatest": true,
"updatedAt": "2026-10-24T12:49:49.071479Z",
"publishedAt": "2026-10-24T12:49:49.071479Z",
"statusChangedAt": "2026-10-24T12:49:49.071479Z"
}
},
"server": {
"name": "io.github.cyanheads/chembl-mcp-server",
"$schema": "https://static.modelcontextprotocol.io/schemas/2025-12-11/server.schema.json",
"remotes": [
{
"url": "https://chembl.caseyjhand.com/mcp",
"type": "streamable-http"
}
],
"version": "0.4.1",
"packages": [
{
"version": "0.4.1",
"transport": {
"type": "stdio"
},
"identifier": "@cyanheads/chembl-mcp-server",
"runtimeHint": "npx",
"registryType": "npm",
"registryBaseUrl": "https://registry.npmjs.org",
"environmentVariables": [
{
"name": "CANVAS_PROVIDER_TYPE",
"format": "string",
"default": "duckdb",
"description": "DataCanvas provider for the bioactivity spill and the chembl_dataframe_* SQL tools; DuckDB is the default. Set to 'none' to disable it: large bioactivity sets then inline a preview but never spill."
},
{
"name": "CHEMBL_API_BASE_URL",
"format": "string",
"default": "https://www.ebi.ac.uk/chembl/api/data",
"description": "Base URL for the ChEMBL REST data API. Override for a private mirror or pinned host."
},
{
"name": "CHEMBL_REQUEST_TIMEOUT_MS",
"format": "string",
"default": "30000",
"description": "Per-attempt timeout in milliseconds for an upstream ChEMBL request, capped by what is left of the call's time budget (45 s for most calls, CHEMBL_SPILL_DEADLINE_MS for a bioactivity spill)."
},
{
"name": "CHEMBL_MAX_PAGE_SIZE",
"format": "string",
"default": "1000",
"description": "Rows per upstream ChEMBL page (max 1000). The bioactivity spill walks pages of this size; an inline bioactivity page requests its limit, capped at this size."
},
{
"name": "CHEMBL_DEFAULT_LIMIT",
"format": "string",
"default": "25",
"description": "Default result limit applied when callers omit it."
},
{
"name": "CHEMBL_MAX_SPILL_ROWS",
"format": "string",
"default": "50000",
"description": "Ceiling on rows chembl_get_bioactivities stages to a DataCanvas table, and so on the upstream page walk behind it. Over the cap the response reports truncated: true and truncated_by: \"row_cap\"."
},
{
"name": "CHEMBL_MAX_CONCURRENT_PAGES",
"format": "string",
"default": "4",
"description": "Most chembl_get_bioactivities spill-page requests in flight at once (1–6), shared by every call on the server."
},
{
"name": "CHEMBL_SPILL_DEADLINE_MS",
"format": "string",
"default": "45000",
"description": "Time budget in milliseconds for one chembl_get_bioactivities spill, its count and page walk (10000–600000). At expiry the rows fetched so far stage with truncated: true and truncated_by: \"time_budget\"."
},
{
"name": "CHEMBL_DATAFRAME_DROP_ENABLED",
"format": "string",
"default": "false",
"description": "Set to 'true' to register the opt-in chembl_dataframe_drop tool (absent from tools/list when off)."
},
{
"name": "MCP_LOG_LEVEL",
"format": "string",
"default": "info",
"description": "Sets the minimum log level for output (e.g., 'debug', 'info', 'warn')."
}
]
},
{
"version": "0.4.1",
"transport": {
"url": "http://localhost:3010/mcp",
"type": "streamable-http"
},
"identifier": "@cyanheads/chembl-mcp-server",
"runtimeHint": "npx",
"registryType": "npm",
"registryBaseUrl": "https://registry.npmjs.org",
"environmentVariables": [
{
"name": "MCP_TRANSPORT_TYPE",
"value": "http",
"format": "string",
"description": "Selects the HTTP transport."
},
{
"name": "MCP_HTTP_HOST",
"format": "string",
"default": "127.0.0.1",
"description": "The hostname for the HTTP server."
},
{
"name": "MCP_HTTP_PORT",
"format": "string",
"default": "3010",
"description": "The port to run the HTTP server on."
},
{
"name": "MCP_HTTP_ENDPOINT_PATH",
"format": "string",
"default": "/mcp",
"description": "The endpoint path for the MCP server."
},
{
"name": "MCP_AUTH_MODE",
"format": "string",
"default": "none",
"description": "Authentication mode to use: 'none', 'jwt', or 'oauth'."
},
{
"name": "MCP_LOG_LEVEL",
"format": "string",
"default": "info",
"description": "Sets the minimum log level for output (e.g., 'debug', 'info', 'warn')."
},
{
"name": "CANVAS_PROVIDER_TYPE",
"format": "string",
"default": "duckdb",
"description": "DataCanvas provider for the bioactivity spill and the chembl_dataframe_* SQL tools; DuckDB is the default. Set to 'none' to disable it: large bioactivity sets then inline a preview but never spill."
},
{
"name": "CHEMBL_API_BASE_URL",
"format": "string",
"default": "https://www.ebi.ac.uk/chembl/api/data",
"description": "Base URL for the ChEMBL REST data API. Override for a private mirror or pinned host."
},
{
"name": "CHEMBL_REQUEST_TIMEOUT_MS",
"format": "string",
"default": "30000",
"description": "Per-attempt timeout in milliseconds for an upstream ChEMBL request, capped by what is left of the call's time budget (45 s for most calls, CHEMBL_SPILL_DEADLINE_MS for a bioactivity spill)."
},
{
"name": "CHEMBL_MAX_PAGE_SIZE",
"format": "string",
"default": "1000",
"description": "Rows per upstream ChEMBL page (max 1000). The bioactivity spill walks pages of this size; an inline bioactivity page requests its limit, capped at this size."
},
{
"name": "CHEMBL_DEFAULT_LIMIT",
"format": "string",
"default": "25",
"description": "Default result limit applied when callers omit it."
},
{
"name": "CHEMBL_MAX_SPILL_ROWS",
"format": "string",
"default": "50000",
"description": "Ceiling on rows chembl_get_bioactivities stages to a DataCanvas table, and so on the upstream page walk behind it. Over the cap the response reports truncated: true and truncated_by: \"row_cap\"."
},
{
"name": "CHEMBL_MAX_CONCURRENT_PAGES",
"format": "string",
"default": "4",
"description": "Most chembl_get_bioactivities spill-page requests in flight at once (1–6), shared by every call on the server."
},
{
"name": "CHEMBL_SPILL_DEADLINE_MS",
"format": "string",
"default": "45000",
"description": "Time budget in milliseconds for one chembl_get_bioactivities spill, its count and page walk (10000–600000). At expiry the rows fetched so far stage with truncated: true and truncated_by: \"time_budget\"."
},
{
"name": "CHEMBL_DATAFRAME_DROP_ENABLED",
"format": "string",
"default": "false",
"description": "Set to 'true' to register the opt-in chembl_dataframe_drop tool (absent from tools/list when off)."
}
]
}
],
"repository": {
"url": "https://github.com/cyanheads/chembl-mcp-server",
"source": "github"
},
"description": "Link compounds to protein targets, rank bioactivity, and look up drug mechanisms and indications."
}
}